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Many millions of kilograms of acetone are consumed in the production of the solvents methyl isobutyl alcohol and methyl isobutyl ketone.

These products arise via an initial aldol condensation to give diacetone alcohol.

Acetone can be produced from the oxidation of ingested isopropanol, or from the spontaneous/enzymatic breakdown of acetoacetate (a ketone body) in ketotic individuals.

It can then be metabolized either by CYP2E1 via methylglyoxal to After that time, during World War I, acetone was produced using acetone-butanol-ethanol fermentation with Clostridium acetobutylicum bacteria, which was developed by Chaim Weizmann (later the first president of Israel) in order to help the British war effort, Acetone is a good solvent for many plastics and some synthetic fibers.

Prior to chemexfoliation, the skin is cleaned and excess fat removed in a process called defatting.

Acetone, Septisol, or a combination of these agents is commonly used in this process.

Acetone was first produced by alchemists during the late Middle Ages via the dry distillation of metal acetates (e.g., lead acetate, which produced "spirit of Saturn" (since the alchemical symbol for lead was also the astrological symbol for the planet Saturn)).

The most hazardous property of acetone is its extreme flammability.

The technique, called acetone vapor bath smoothing, involves placing the printed part in a sealed chamber containing a small amount of acetone, and heating to around 80 degrees Celsius for 10 minutes. The acetone condenses evenly all over the part, causing the surface to soften and liquefy.

Surface tension then smooths the semi-liquid plastic.

Acetone can be cooled with dry ice to −78 °C without freezing; acetone/dry ice baths are commonly used to conduct reactions at low temperatures.

Acetone is fluorescent under ultraviolet light, and its vapor can be used as a fluorescent tracer in fluid flow experiments.

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